Translational thermotolerance in Saccharomyces cerevisiae
نویسندگان
چکیده
منابع مشابه
Synergy between trehalose and Hsp104 for thermotolerance in Saccharomyces cerevisiae.
We isolated a mutant strain unable to acquire heat shock resistance in stationary phase. Two mutations contributed to this phenotype. One mutation was at the TPS2 locus, which encodes trehalose-6-phosphate phosphatase. The mutant fails to make trehalose and accumulates trehalose-6-phosphate. The other mutation was at the HSP104 locus. Gene disruptions showed that tps2 and hsp104 null mutants ea...
متن کاملThermotolerance in Saccharomyces cerevisiae: the Yin and Yang of trehalose.
Trehalose, a sugar produced by a wide variety of organisms, has long been known for its role in protecting certain organisms from desiccation. Recent work in yeast indicates that trehalose also promotes survival under conditions of extreme heat, by enabling proteins to retain their native conformation at elevated temperatures and suppressing the aggregation of denatured proteins. The latter pro...
متن کاملSsd1 is required for thermotolerance and Hsp104-mediated protein disaggregation in Saccharomyces cerevisiae.
In the budding yeast Saccharomyces cerevisiae, the Hsp104-mediated disaggregation of protein aggregates is essential for thermotolerance and to facilitate the maintenance of prions. In humans, protein aggregation is associated with neuronal death and dysfunction in many neurodegenerative diseases. Mechanisms of aggregation surveillance that regulate protein disaggregation are likely to play a m...
متن کاملOxygen availability strongly affects chronological lifespan and thermotolerance in batch cultures of Saccharomyces cerevisiae
Stationary-phase (SP) batch cultures of Saccharomyces cerevisiae, in which growth has been arrested by carbon-source depletion, are widely applied to study chronological lifespan, quiescence and SP-associated robustness. Based on this type of experiments, typically performed under aerobic conditions, several roles of oxygen in aging have been proposed. However, SP in anaerobic yeast cultures ha...
متن کاملCharacterization of Encapsulated Berberine in Yeast Cells of Saccharomyces cerevisiae
Berberine was loaded in yeast cells of Saccharomyces cerevisiaeas a novel pharmaceutical carrier to improve the treatment ofmany diseases. The yeast-encapsulated active materialsshowedhigh stability and bioavailability due to the enhanced solubility and sustained releasing. In this study, different characteristics of prepared berberine loaded yeast cells (loading capacity, release kinetic order...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Stress & Chaperones
سال: 1996
ISSN: 1355-8145,1466-1268
DOI: 10.1379/1466-1268(1996)001<0070:ttisc>2.3.co;2